Academic Journal
Increased alcohol intake is associated with radiographic severity of knee and hand osteoarthritis in men
| Title: | Increased alcohol intake is associated with radiographic severity of knee and hand osteoarthritis in men |
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| Authors: | Haimuzi Xu, Ji-Hyoun Kang, Sung-Eun Choi, Dong-Jin Park, Sun-Seog Kweon, Young-Hoon Lee, Hye-Yeon Kim, Jung-Kil Lee, Min-Ho Shin, Shin-Seok Lee |
| Source: | Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024) |
| Publisher Information: | Nature Portfolio, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Osteoarthritis, Alcohol, Knee, Hand, Medicine, Science |
| More Details: | Abstract Observational studies have shown controversial associations between alcohol intake and radiographic osteoarthritis (OA). This study investigated whether this association was causal using a Mendelian randomization (MR) study in a population-based cohort in Korean. The study enrolled 2429 subjects (1058 men, 1371 women) from the Dong-gu Study. X-rays of the hand and knee joints were scored using a semi-quantitative grading system to calculate the total score of the hand and knee joints. ALDH2 rs671 genotyping was performed by high-resolution melting analysis. MR instrumental variable analysis and observational multivariable regression analysis were used to estimate the association between genetically predicted alcohol intake and the radiographic severity of OA. Subjects with the G/G genotype had a higher current alcohol intake than those with the G/A and A/A genotypes in both men and women (all P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-63559-x |
| Access URL: | https://doaj.org/article/01e58eda068e4c91b715e7103888243f |
| Accession Number: | edsdoj.01e58eda068e4c91b715e7103888243f |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-024-63559-x |
| Published in: | Scientific Reports |
| Language: | English |