Bibliographic Details
| Title: |
A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling |
| Authors: |
Qi-qi Liu, Wei-wei Wu, Jian Yang, Rui-bin Wang, Ling-ling Yuan, Pei-zhao Peng, Mao-yun Zeng, Ke Yu |
| Source: |
Mediators of Inflammation, Vol 2023 (2023) |
| Publisher Information: |
Wiley, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Pathology |
| Subject Terms: |
Pathology, RB1-214 |
| More Details: |
In this study, we examined the effect of the GP130-targeting molecule, LMT-28, on lipopolysaccharide- (LPS-) induced bone resorption around implants in diabetic models using in vitro and rat animal experiments. First, LMT-28 was added to osteoblasts stimulated by LPS and advanced glycation end products (AGEs), and nuclear factor-κB receptor-activating factor ligand (RANKL) and associated pathways were evaluated. Then, LMT-28 was administered by gavage at 0.23 mg/kg once every 5 days for 2 weeks to type 2 diabetic rats with peri-implantitis induced by LPS injection and silk ligature. The expression of IL-6 and RANKL was evaluated by immunohistochemistry, and the bone resorption around implants was evaluated by microcomputed tomography. The results showed that LMT-28 downregulated the expression of RANKL through the JAK2/STAT3 signaling pathway in osteoblasts stimulated by LPS and AGEs, reduced bone resorption around implants with peri-implantitis, decreased the expression of IL-6 and RANKL, and decreased osteoclast activity in type 2 diabetic rats. This study confirmed the ability of LMT-28 to reduce LPS-induced bone resorption around implants in diabetic rats. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1466-1861 |
| Relation: |
https://doaj.org/toc/1466-1861 |
| DOI: |
10.1155/2023/9330439 |
| Access URL: |
https://doaj.org/article/01cfe5bd5507465aad1be8dcdb18a0b0 |
| Accession Number: |
edsdoj.01cfe5bd5507465aad1be8dcdb18a0b0 |
| Database: |
Directory of Open Access Journals |
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