Academic Journal
Glycyrrhizin attenuates renal inflammation in a mouse Con A-hepatitis model via the IL-25/M2 axis
| Title: | Glycyrrhizin attenuates renal inflammation in a mouse Con A-hepatitis model via the IL-25/M2 axis |
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| Authors: | Lingyun Li, Yuanyue Zhang, Zhongyan Wang, Xiangyu Chen, Min Fang |
| Source: | Renal Failure, Vol 46, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Diseases of the genitourinary system. Urology |
| Subject Terms: | Glycyrrhizin, renal inflammation, Con A, IL-25, type 2 macrophages, Diseases of the genitourinary system. Urology, RC870-923 |
| More Details: | Glycyrrhizin (GL) has immunoregulatory effects on various inflammatory diseases including hepatitis and nephritis. However, the mechanisms underlying the anti-inflammatory effect of GL on renal inflammation are not fully understood. Hepatorenal syndrome (HRS) is a functional acute renal impairment that occurs in severe liver disease, and we found that kidney injury also occurs in Con A-induced experimental hepatitis in mice. We previously found that GL can alleviate Con A-induced hepatitis by regulating the expression of IL-25 in the liver. We wanted to investigate whether GL can alleviate Con A-induced nephritis by regulating IL-25. IL-25 regulates inflammation by modulating type 2 immune responses, but the mechanism by which IL-25 affects kidney disease remains unclear. In this study, we found that the administration of GL enhanced the expression of IL-25 in renal tissues; the latter promoted the generation of type 2 macrophages (M2), which inhibited inflammation in the kidney caused by Con A challenge. IL-25 promoted the secretion of the inhibitory cytokine IL-10 by macrophages but inhibited the expression of the inflammatory cytokine IL-1β by macrophages. Moreover, IL-25 downregulated the Con A-mediated expression of Toll-like receptor (TLR) 4 on macrophages. By comparing the roles of TLR2 and TLR4, we found that TLR4 is required for the immunoregulatory effect of IL-25 on macrophages. Our data revealed that GL has anti-inflammatory effects on Con A-induced kidney injury and that the GL/IL-25/M2 axis participates in the anti-inflammatory process. This study suggested that GL is a potential therapeutic for protecting against acute kidney injury. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0886022X 1525-6049 0886-022X |
| Relation: | https://doaj.org/toc/0886-022X; https://doaj.org/toc/1525-6049 |
| DOI: | 10.1080/0886022X.2024.2356023 |
| Access URL: | https://doaj.org/article/01b890af1b0f44a2a1b6b4c0f1daf860 |
| Accession Number: | edsdoj.01b890af1b0f44a2a1b6b4c0f1daf860 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 0886022X 15256049 |
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| DOI: | 10.1080/0886022X.2024.2356023 |
| Published in: | Renal Failure |
| Language: | English |