Academic Journal
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
| Title: | Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis |
|---|---|
| Authors: | Ying Han, Jielai Yang, Weiwei Zhao, Haimang Wang, Yulong Sun, Yuji Chen, Jing Luo, Lianfu Deng, Xiangyang Xu, Wenguo Cui, Hongyu Zhang |
| Source: | Bioactive Materials, Vol 6, Iss 10, Pp 3596-3607 (2021) |
| Publisher Information: | KeAi Communications Co., Ltd., 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| Subject Terms: | Microfluidics, Hydrogel microspheres, Catecholamine chemistry, Hydration lubrication, Drug delivery, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| More Details: | The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive inflammatory response dominate the mechanism. In this study, bioinspired by the super-lubrication property of cartilage and catecholamine chemistry of mussel, we successfully developed injectable hydrogel microspheres with enhanced lubrication and controllable drug release for OA treatment. Particularly, the lubricating microspheres (GelMA@DMA-MPC) were fabricated by dip coating a self-adhesive polymer (DMA-MPC, synthesized by free radical copolymerization) on superficial surface of photo-crosslinked methacrylate gelatin hydrogel microspheres (GelMA, prepared via microfluidic technology), and encapsulated with an anti-inflammatory drug of diclofenac sodium (DS) to achieve the dual-functional performance. The tribological test and drug release test showed the enhanced lubrication and sustained drug release of the GelMA@DMA-MPC microspheres. In addition, the functionalized microspheres were intra-articularly injected into the rat knee joint with an OA model, and the biological tests including qRT-PCR, immunofluorescence staining assay, X-ray radiography and histological staining assay all revealed that the biocompatible microspheres provided significant therapeutic effect against the development of OA. In summary, the injectable hydrogel microspheres developed herein greatly improved lubrication and achieved sustained local drug release, therefore representing a facile and promising technique for the treatment of OA. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-199X |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452199X21001341; https://doaj.org/toc/2452-199X |
| DOI: | 10.1016/j.bioactmat.2021.03.022 |
| Access URL: | https://doaj.org/article/016e9427b9c44095b4b16e554ec8b137 |
| Accession Number: | edsdoj.016e9427b9c44095b4b16e554ec8b137 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2452199X |
|---|---|
| DOI: | 10.1016/j.bioactmat.2021.03.022 |
| Published in: | Bioactive Materials |
| Language: | English |