Bibliographic Details
| Title: |
Determining the screening frequency for sexually transmitted infections for people who use HIV pre-exposure prophylaxis: a systematic review and meta-analysis |
| Authors: |
Cham-mill Kim, Victor Zhao, Maeve Brito De Mello, Rachel Baggaley, Cheryl C. Johnson, Erica Spielman, Christopher K. Fairley, Lei Zhang, Henry de Vries, Jeffrey Klausner, Rui Zhao, Jason J. Ong |
| Source: |
International Journal of Infectious Diseases, Vol 129, Iss , Pp 181-187 (2023) |
| Publisher Information: |
Elsevier, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
HIV, PrEP, Pre-exposure prophylaxis, Sexually transmitted infections, Screening, Infectious and parasitic diseases, RC109-216 |
| More Details: |
ABSTRACT: Objectives: Although the World Health Organization recommends ‘frequent’ screening of sexually transmitted infections (STI) for people who use pre-exposure prophylaxis for HIV, there is no evidence for optimal frequency. Methods: We searched five databases and used random-effects meta-analysis to calculate pooled estimates of STI test positivity. We narratively synthesized data on secondary outcomes, including adherence to recommended STI screening frequency and changes in STI epidemiology. Results: Of 7477 studies, we included 38 for the meta-analysis and 11 for secondary outcomes. With 2-3 monthly STI screening, the pooled positivity was 0.20 (95% confidence interval [CI]: 0.15-0.25) for chlamydia, 0.17 (95% CI: 0.12-0.22) for gonorrhea, and 0.07 (95% CI: 0.05-0.08) for syphilis. For chlamydia and gonorrhea, the positivity was approximately 50% and 75% lower, respectively, in studies that screened 4-6 monthly vs 2-3 monthly. There was no significant difference in the positivity for syphilis in studies that screened 4-6 monthly compared to 2-3 monthly. Adherence of clients to recommended screening frequency varied significantly (39-94%) depending on population and country. Modeling studies suggest more frequent STI screening could reduce incidence. Conclusion: Although more frequent STI screening could reduce delayed diagnoses and incidence, there remain significant knowledge gaps regarding the optimal STI screening frequency. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1201-9712 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1201971223000073; https://doaj.org/toc/1201-9712 |
| DOI: |
10.1016/j.ijid.2023.01.007 |
| Access URL: |
https://doaj.org/article/01511c11f6964e7283192953b42e448b |
| Accession Number: |
edsdoj.01511c11f6964e7283192953b42e448b |
| Database: |
Directory of Open Access Journals |
