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Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

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Title: Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
Authors: Natalia Fintelman-Rodrigues, Aline P.D. da Silva, Monique Cristina dos Santos, Felipe B. Saraiva, Marcelo A. Ferreira, João Gesto, Danielle A.S. Rodrigues, André M. Vale, Isaclaudia G. de Azevedo, Vinícius C. Soares, Hui Jiang, Hongdong Tan, Diogo A. Tschoeke, Carolina Q. Sacramento, Fernando A. Bozza, Carlos M. Morel, Patrícia T. Bozza, Thiago Moreno L. Souza
Source: Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1446-1453 (2021)
Publisher Information: Centers for Disease Control and Prevention, 2021.
Publication Year: 2021
Collection: LCC:Medicine
LCC:Infectious and parasitic diseases
Subject Terms: COVID-19, coronavirus disease, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, Medicine, Infectious and parasitic diseases, RC109-216
More Details: The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1080-6040
1080-6059
Relation: https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059
DOI: 10.3201/eid2705.204912
Access URL: https://doaj.org/article/012ca42c98e74c1197d39a712f22fc7d
Accession Number: edsdoj.012ca42c98e74c1197d39a712f22fc7d
Database: Directory of Open Access Journals
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  Data: The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
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