Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
| Title: | Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil |
|---|---|
| Authors: | Natalia Fintelman-Rodrigues, Aline P.D. da Silva, Monique Cristina dos Santos, Felipe B. Saraiva, Marcelo A. Ferreira, João Gesto, Danielle A.S. Rodrigues, André M. Vale, Isaclaudia G. de Azevedo, Vinícius C. Soares, Hui Jiang, Hongdong Tan, Diogo A. Tschoeke, Carolina Q. Sacramento, Fernando A. Bozza, Carlos M. Morel, Patrícia T. Bozza, Thiago Moreno L. Souza |
| Source: | Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1446-1453 (2021) |
| Publisher Information: | Centers for Disease Control and Prevention, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine LCC:Infectious and parasitic diseases |
| Subject Terms: | COVID-19, coronavirus disease, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, Medicine, Infectious and parasitic diseases, RC109-216 |
| More Details: | The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1080-6040 1080-6059 |
| Relation: | https://wwwnc.cdc.gov/eid/article/27/5/20-4912_article; https://doaj.org/toc/1080-6040; https://doaj.org/toc/1080-6059 |
| DOI: | 10.3201/eid2705.204912 |
| Access URL: | https://doaj.org/article/012ca42c98e74c1197d39a712f22fc7d |
| Accession Number: | edsdoj.012ca42c98e74c1197d39a712f22fc7d |
| Database: | Directory of Open Access Journals |
| ISSN: | 10806040 10806059 |
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| DOI: | 10.3201/eid2705.204912 |
| Published in: | Emerging Infectious Diseases |
| Language: | English |