Bibliographic Details
| Title: |
Replenishing the Aged Brains: Targeting Oligodendrocytes and Myelination? |
| Authors: |
Xi Zhang, Nanxin Huang, Lan Xiao, Fei Wang, Tao Li |
| Source: |
Frontiers in Aging Neuroscience, Vol 13 (2021) |
| Publisher Information: |
Frontiers Media S.A., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
oligodendrocyte, OPC, myelinogenesis, aging, neurofunctional decline, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Aging affects almost all the aspects of brain functions, but the mechanisms remain largely undefined. Increasing number of literatures have manifested the important role of glial cells in regulating the aging process. Oligodendroglial lineage cell is a major type of glia in central nervous system (CNS), composed of mature oligodendrocytes (OLs), and oligodendroglia precursor cells (OPCs). OLs produce myelin sheaths that insulate axons and provide metabolic support to meet the energy demand. OPCs maintain the population throughout lifetime with the abilities to proliferate and differentiate into OLs. Increasing evidence has shown that oligodendroglial cells display active dynamics in adult and aging CNS, which is extensively involved in age-related brain function decline in the elderly. In this review, we summarized present knowledge about dynamic changes of oligodendroglial lineage cells during normal aging and discussed their potential roles in age-related functional decline. Especially, focused on declined myelinogenesis during aging and underlying mechanisms. Clarifying those oligodendroglial changes and their effects on neurofunctional decline may provide new insights in understanding aging associated brain function declines. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1663-4365 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnagi.2021.760200/full; https://doaj.org/toc/1663-4365 |
| DOI: |
10.3389/fnagi.2021.760200 |
| Access URL: |
https://doaj.org/article/010fd8995de44d008fc6088ae8d4600d |
| Accession Number: |
edsdoj.010fd8995de44d008fc6088ae8d4600d |
| Database: |
Directory of Open Access Journals |
