Weight Changes in Type 2 Diabetes and Cancer Risk: A Latent Class Trajectory Model Study
| Title: | Weight Changes in Type 2 Diabetes and Cancer Risk: A Latent Class Trajectory Model Study |
|---|---|
| Authors: | Britt W. Jensen, Charlotte Watson, Nophar Geifman, Jennifer L. Baker, Ellena Badrick, Andrew G. Renehan |
| Source: | Obesity Facts, Pp 1-10 (2021) |
| Publisher Information: | Karger Publishers, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| Subject Terms: | body mass index, latent classes, diabetes, cancer, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| More Details: | Introduction: Body mass index (BMI) is often elevated at type 2 diabetes (T2D) diagnosis. Using latent class trajectory modelling (LCTM) of BMI, we examined whether weight loss after diagnosis influenced cancer incidence and all-cause mortality. Methods: From 1995 to 2010, we identified 7,708 patients with T2D from the Salford Integrated Record database (UK) and linked to the cancer registry for information on obesity-related cancer (ORC), non-ORC; and all-cause mortality. Repeated BMIs were used to construct sex-specific latent class trajectories. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models. Results: Four sex-specific BMI classes were identified; stable-overweight, stable-obese, obese-slightly-decreasing, and obese-steeply-decreasing; comprising 41%, 45%, 13%, and 1% of women, and 45%, 37%, 17%, and 1% of men, respectively. In women, the stable-obese class had similar ORC risks as the obese-slightly-decreasing class, whereas the stable-overweight class had lower risks. In men, the obese-slightly-decreasing class had higher risks of ORC (HR = 1.86, 95% CI: 1.05–3.32) than the stable-obese class, while the stable-overweight class had similar risks No associations were observed for non-ORC. Compared to the stable-obese class, women (HR = 1.60, 95% CI: 0.99–2.58) and men (HR = 2.37, 95% CI: 1.66–3.39) in the obese-slightly-decreasing class had elevated mortality. No associations were observed for the stable-overweight classes. Conclusion: Patients who lost weight after T2D diagnosis had higher risks for ORC (in men) and higher all-cause mortality (both genders) than patients with stable obesity. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1662-4025 1662-4033 |
| Relation: | https://www.karger.com/Article/FullText/520200; https://doaj.org/toc/1662-4025; https://doaj.org/toc/1662-4033 |
| DOI: | 10.1159/000520200 |
| Access URL: | https://doaj.org/article/00f3ab36ebe747e4b63b10bd2fa0d03c |
| Accession Number: | edsdoj.00f3ab36ebe747e4b63b10bd2fa0d03c |
| Database: | Directory of Open Access Journals |
| ISSN: | 16624025 16624033 |
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| DOI: | 10.1159/000520200 |
| Published in: | Obesity Facts |
| Language: | English |