Academic Journal
TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells
| Title: | TGF-β/SMAD canonical pathway induces the expression of transcriptional cofactor TAZ in liver cancer cells |
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| Authors: | Diana G. Ríos-López, Angeles C. Tecalco-Cruz, David Martínez-Pastor, Marcela Sosa-Garrocho, Gustavo Tapia-Urzúa, Yuli Aranda-López, Bibiana Ortega-Domínguez, Félix Recillas-Targa, Genaro Vázquez-Victorio, Marina Macías-Silva |
| Source: | Heliyon, Vol 9, Iss 11, Pp e21519- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | TGF-β cytokine, Hippo-pathway, TAZ cofactor, HepG2 cells, Liver cancer, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | The TGF-β and Hippo pathways are critical for liver size control, regeneration, and cancer progression. The transcriptional cofactor TAZ, also named WWTR1, is a downstream effector of Hippo pathway and plays a key role in the maintenance of liver physiological functions. However, the up-regulation of TAZ expression has been associated with liver cancer progression. Recent evidence shows crosstalk of TGF-β and Hippo pathways, since TGF-β modulates TAZ expression through different mechanisms in a cellular context-dependent manner but supposedly independent of SMADs. Here, we evaluate the molecular interplay between TGF-β pathway and TAZ expression and observe that TGF-β induces TAZ expression through SMAD canonical pathway in liver cancer HepG2 cells. Therefore, TAZ cofactor is a primary target of TGF-β/SMAD-signaling, one of the pathways altered in liver cancer. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023087273; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e21519 |
| Access URL: | https://doaj.org/article/ad00e525b770493ca6f0623c00db2fff |
| Accession Number: | edsdoj.00e525b770493ca6f0623c00db2fff |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e21519 |
| Published in: | Heliyon |
| Language: | English |