Academic Journal
Post-surgery sequelae unrelated to disease progression and chemotherapy revealed in follow-up of patients with stage III colon cancerResearch in context
| Title: | Post-surgery sequelae unrelated to disease progression and chemotherapy revealed in follow-up of patients with stage III colon cancerResearch in context |
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| Authors: | Alexia Mirandola, Andrei Kudriavtsev, Catalina Isabel Cofre Muñoz, Raquel Comas Navarro, Marco Macagno, Saidi Daoud, Cynthia Sanchez, Brice Pastor, Ekaterina Pisareva, Mireia Sanchis Marin, Javier Gonzalo Ruiz, Alejandro Piris, Ariadna Garcia Rodriguez, Nadia Saoudi Gonzalez, Ana Vivancos, Virginia Quarà, Alfredo Mellano, Felice Borghi, Giorgio Corti, Caterina Marchiò, Anna Sapino, Alice Bartolini, Giovanni Crisafulli, Alberto Bardelli, Massimo Di Maio, Gerald Lossaint, Florence Frayssinoux, Evelyne Crapez, Marc Ychou, Ramon Salazar Soler, Elisabetta Fenocchio, Paula X. Fernandez Calotti, Thibault Mazard, Cristina Santos Vivas, Elena Elez, Federica Di Nicolantonio, Alain R. Thierry |
| Source: | EBioMedicine, Vol 108, Iss , Pp 105352- (2024) |
| Publisher Information: | Elsevier, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | Diagnostic, Tumour biology, Colorectal cancer, Circulating DNA, Neutrophil extracellular traps, Post-surgery, Medicine, Medicine (General), R5-920 |
| More Details: | Summary: Background: We studied the poorly-known dynamics of circulating DNA (cir-nDNA), as monitored prospectively over an extended post-surgery period, in patients with cancer. Methods: On patients with stage III colon cancer (N = 120), using personalised molecular tags we carried out the prospective, multicenter, blinded cohort study of the post-surgery serial analysis of cir-nDNA concentration. 74 patients were included and 357 plasma samples tested. Findings: During post-operative follow-up, the patients’ median cir-nDNA concentration was greater (P 18 months post-surgery, the data suggest that the persistence of NETs formation is not due to the adjuvant CT. Interpretation: (1), Given the inter-patient heterogeneity, the post-surgery cir-nDNA level cannot be considered a reliable value, and caution must be exercised when determining mutation allele frequency or the mutation status; and (2), specific studies must be undertaken to investigate the possible clinical impact of the persistent, low-grade inflammation resulting from elevated NETs levels, such as observed in these post-surgery patients, given that such levels are known to potentially induce adverse cardiovascular or thrombotic events. Funding: This work was supported by the H2020 European ERA-NET grant on Translational Cancer Research (TRANSCAN-2). |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3964 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352396424003888; https://doaj.org/toc/2352-3964 |
| DOI: | 10.1016/j.ebiom.2024.105352 |
| Access URL: | https://doaj.org/article/00bd9725b0694cf5a6a8cd91ec3b094f |
| Accession Number: | edsdoj.00bd9725b0694cf5a6a8cd91ec3b094f |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523964 |
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| DOI: | 10.1016/j.ebiom.2024.105352 |
| Published in: | EBioMedicine |
| Language: | English |