Bibliographic Details
| Title: |
Developmental endothelial locus-1 as a potential biomarker for the incidence of acute exacerbation in patients with chronic obstructive pulmonary disease |
| Authors: |
Dong-Hyun Joo, Kyoung-Hee Lee, Chang-Hoon Lee, Jisu Woo, Jiyeon Kim, Seoung Ju Park, Chin Kook Rhee, Won-Yeon Lee, Dongil Park, Jae Seung Lee, Ki-Suck Jung, Kwang Ha Yoo, Chul-Gyu Yoo |
| Source: |
Respiratory Research, Vol 22, Iss 1, Pp 1-9 (2021) |
| Publisher Information: |
BMC, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the respiratory system |
| Subject Terms: |
Chronic obstructive pulmonary disease, Developmental endothelial locus-1, Disease progression, Biomarkers, Animal disease models, Diseases of the respiratory system, RC705-779 |
| More Details: |
Abstract Background Despite the high disease burden of chronic obstructive pulmonary disease (COPD) and risk of acute COPD exacerbation, few COPD biomarkers are available. As developmental endothelial locus-1 (DEL-1) has been proposed to possess beneficial effects, including anti-inflammatory effects, we hypothesized that DEL-1 could be a blood biomarker for COPD. Objective To elucidate the role of plasma DEL-1 as a biomarker of COPD in terms of pathogenesis and for predicting acute exacerbation. Methods Cigarette smoke extract (CSE) or saline was intratracheally administered to wild-type (WT) and DEL-1 knockout (KO) C57BL/6 mice. Subsequently, lung sections were obtained to quantify the degree of emphysema using the mean linear intercept (MLI). Additionally, plasma DEL-1 levels were compared between COPD and non-COPD participants recruited in ongoing prospective cohorts. Using negative binomial regression analysis, the association between the plasma DEL-1 level and subsequent acute exacerbation risk was evaluated in patients with COPD. Results In the in vivo study, DEL-1 KO induced emphysema (KO saline vs. WT saline; P = 0.003) and augmented CSE-induced emphysema (KO CSE vs. WT CSE; P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1465-993X |
| Relation: |
https://doaj.org/toc/1465-993X |
| DOI: |
10.1186/s12931-021-01878-7 |
| Access URL: |
https://doaj.org/article/00b2ae17ff3142a9a1a5eaeb6942b41a |
| Accession Number: |
edsdoj.00b2ae17ff3142a9a1a5eaeb6942b41a |
| Database: |
Directory of Open Access Journals |
