A cost-effectiveness analysis of PHiD-CV compared to PCV13 in a national immunization program setting in Tunisia
| Title: | A cost-effectiveness analysis of PHiD-CV compared to PCV13 in a national immunization program setting in Tunisia |
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| Authors: | Youness Lagoubi, Mohamed Tahar Sfar, Jorge A. Gomez |
| Source: | Human Vaccines & Immunotherapeutics, Vol 18, Iss 5 (2022) |
| Publisher Information: | Taylor & Francis Group, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Immunologic diseases. Allergy LCC:Therapeutics. Pharmacology |
| Subject Terms: | streptococcus pneumoniae, pneumococcal conjugate vaccine, 10-valent pneumococcal non-typeable haemophilus influenzae protein d conjugate vaccine, 13-valent pneumococcal conjugate vaccine, pcv10, pcv13, cost-effectiveness, tunisia, invasive pneumococcal disease, acute otitis media, phid-cv, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Background In response to the substantial clinical and economic burden of diseases caused by Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) in Tunisia, the 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) was recently introduced into the national immunization program. However, there has yet to be a full-scale health economic analysis comparing currently available pneumococcal conjugate vaccines (PCVs) in Tunisia. Methods A Markov model that simulated the disease processes of invasive pneumococcal disease (IPD), pneumonia, and acute otitis media (AOM) over a newborn cohort lifetime was used to evaluate the cost-effectiveness/utility of PHiD-CV and the 13-valent pneumococcal conjugate vaccine (PCV13) from payer’s perspective, using 3% discounting. Vaccine effects were considered for up to 9 years of age. Results Vaccination with PHiD-CV or PCV13 was estimated to avert approximately 700 cases of IPD (200 meningitis, 500 bacteremia), and around 5,000 cases of all-cause pneumonia. However, PHiD-CV vaccination was estimated to avert around 4,000 additional AOM cases (18,000) versus PCV13 (14,000). Both PCVs were demonstrated to be cost-effective interventions, but PHiD-CV was estimated to generate additional cost savings of almost $1 million US dollars (USD) with similar levels of clinical benefits. An additional scenario which incorporated serotype-specific vaccine efficacy found no significant change in overall results. Conclusion PCVs are a cost-effective strategy to relieve the burden associated with diseases caused by S. pneumoniae and NTHi in Tunisia. PHiD-CV is more cost-effective than PCV13, generating similar health benefits, at a reduced net cost of almost $1 million USD per vaccinated cohort. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2164-5515 2164-554X 21645515 |
| Relation: | https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X |
| DOI: | 10.1080/21645515.2022.2079305 |
| Access URL: | https://doaj.org/article/cddce0097de54bbb90675bec9de910c3 |
| Accession Number: | edsdoj.0097de54bbb90675bec9de910c3 |
| Database: | Directory of Open Access Journals |
| ISSN: | 21645515 2164554X |
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| DOI: | 10.1080/21645515.2022.2079305 |
| Published in: | Human Vaccines & Immunotherapeutics |
| Language: | English |