Bibliographic Details
| Title: |
T cell exhaustion methylation signature drives differential immune responses in glioblastoma |
| Authors: |
Feng Chen, Wen-Bo Qian, Zhen-Hua Chen, Jun Qian, Chun Luo |
| Source: |
Discover Oncology, Vol 15, Iss 1, Pp 1-13 (2024) |
| Publisher Information: |
Springer, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Consensus clustering, Glioblastoma, Survival analysis, T cell exhaustion, TEXM signature, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract Background Methylation-related signatures play crucial roles in tumorigenesis and progression. However, their roles in the immune response in primary glioblastoma (GBM) remains unclear. Methods We analyzed the differential expression of specific members of T cell exhaustion-related pathways in GBM from the perspective of T cell exhaustion. We further screened for significantly negatively correlated methylation sites as candidate methylation markers for T cell exhaustion. Using consensus clustering, we divided the samples into two categories with significant differences in overall survival (OS). We then performed univariate and multivariate Cox regression analyses to construct the T Cell Exhaustion Methylation (TEXM) signature. Finally, we confirmed that this signature served as an independent prognostic factor, and further characterized it in terms of drug resistance and immunotherapy. Results We identified 95 significantly differentially expressed T cell exhaustion-related genes and 51 methylation markers associated with T cell exhaustion. The cancer samples were classified according to methylation site markers, thus indicating two subtypes with significant differences in OS: subtype A and subtype B. Tumor scores, stromal scores, tumor purity, and ESTIMATE scores all showed significant differences between subtypes (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2730-6011 |
| Relation: |
https://doaj.org/toc/2730-6011 |
| DOI: |
10.1007/s12672-024-01412-3 |
| Access URL: |
https://doaj.org/article/ed0068d59fdf4a25a39eba7745a7b341 |
| Accession Number: |
edsdoj.0068d59fdf4a25a39eba7745a7b341 |
| Database: |
Directory of Open Access Journals |
