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Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model

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Title: Reproducing extracellular matrix adverse remodelling of non-ST myocardial infarction in a large animal model
Authors: Paolo Contessotto, Renza Spelat, Federico Ferro, Vaidas Vysockas, Aušra Krivickienė, Chunsheng Jin, Sandrine Chantepie, Clizia Chinello, Audrys G. Pauza, Camilla Valente, Mindaugas Rackauskas, Alvise Casara, Vilma Zigmantaitė, Fulvio Magni, Dulce Papy-Garcia, Niclas G. Karlsson, Eglė Ereminienė, Abhay Pandit, Mark Da Costa
Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Publisher Information: Nature Portfolio, 2023.
Publication Year: 2023
Collection: LCC:Science
Subject Terms: Science
More Details: The study of the pathophysiology and possible interventions for non-ST-segment elevation myocardial infarction is hindered by the lack of a reproducible pre-clinical model. Here, authors develop an ovine model to reproduce post-ischemic remodeling in non-ST myocardial infarction and reveal distinct complex sugar moieties in cellular membranes and extracellular matrix patterns in infarcted tissue.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-023-36350-1
Access URL: https://doaj.org/article/006423bd42ef408ab58fac9fefcc939e
Accession Number: edsdoj.006423bd42ef408ab58fac9fefcc939e
Database: Directory of Open Access Journals
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  Data: The study of the pathophysiology and possible interventions for non-ST-segment elevation myocardial infarction is hindered by the lack of a reproducible pre-clinical model. Here, authors develop an ovine model to reproduce post-ischemic remodeling in non-ST myocardial infarction and reveal distinct complex sugar moieties in cellular membranes and extracellular matrix patterns in infarcted tissue.
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