Academic Journal

A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome

Bibliographic Details
Title:	A sneak peek into chronic glucose exposure and insulin secretion impairment through translatome
Authors:	Grace Aprilia Helena, Shoen Kume
Source:	Journal of Diabetes Investigation, Vol 15, Iss 9, Pp 1174-1176 (2024)
Publisher Information:	Wiley, 2024.
Publication Year:	2024
Collection:	LCC:Diseases of the endocrine glands. Clinical endocrinology
Subject Terms:	Glucose, Insulin secretion, Translation, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
More Details:	Diabetes is an epidemic caused by a multitude of factors. Despite the studies attempting to unravel its mechanism, there is still more to discover about glucose–insulin dynamics. In a recent issue of the Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells.Journal of Clinical Investigation, Cheruiyot et al. uncovered a translational regulatory circuit during β‐cell glucose toxicity that inherently affects the translational makeup and protein expression in functioning β‐cells. Their multiomics approach might provide a deeper understanding of high glucose and translational regulation of genes involved in β‐cell insulin impairment caused by prolonged high‐glucose exposure.
Document Type:	article
File Description:	electronic resource
Language:	English
ISSN:	2040-1124 2040-1116
Relation:	https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124
DOI:	10.1111/jdi.14258
Access URL:	https://doaj.org/article/001881a045ab4b15885934bf4553a0be
Accession Number:	edsdoj.001881a045ab4b15885934bf4553a0be
Database:	Directory of Open Access Journals

More Details
ISSN:	20401124 20401116
DOI:	10.1111/jdi.14258
Published in:	Journal of Diabetes Investigation
Language:	English