Ca2+ Signaling and Heart Rhythm
| Title: | Ca2+ Signaling and Heart Rhythm |
|---|---|
| Authors: | Christopher L.-H. Huang, Yunbo Ke, R. John Solaro, Ming Lei |
| Publisher Information: | Frontiers Media SA, 2016. |
| Publication Year: | 2016 |
| Subject Terms: | QP1-981, Q1-390, Heart, Pak1, SA node, STIM1, TRPC, Ca2+, Orai1, PP2A, voltage gated Ca2+ channels, Physiology |
| More Details: | Ca2+ is a key second messenger in the intricate workings of the heart. In cardiac myocytes, Ca2+ signaling controls or modulates electrophysiological function, excitation-contraction coupling, contractile function, energy balance, cell death, and gene transcription. Thus, diverse Ca2+-dependent regulatory processes occur simultaneously within a cell. Yet, distinct signals can be resolved by local Ca2+ sensitive protein complexes and differential Ca2+ signal integration. In addition to its importance to normal cardiac function, such regulation is also crucial in disease conditions. Ca2+ is likely involved in ectopic cardiac rhythms in both atrial and ventricular tissues through generating triggered activity often appearing as delayed afterdepolarisations, particularly following cellular Ca overloading. Recent studies also implicate Ca2+ in Na+ channel expression and properties with consequences for conduction velocity and therefore arrhythmic substrate. At the cellular level, such regulation involves control of the activity of membrane ion channels and Ca2+ handling proteins. These in turn involve multiple extra- and intracellular signaling pathways. This e-book assembles review and original articles from experts in this field. It summarises major recent progress bearing on roles of Ca2+ in cardiac electrophysiological function encompassing both normal and abnormal cardiac function. These extend from physiological roles of Ca2+ signaling in pacemaker function, in particular generation of sino-atrial pacemaker potentials, to pathological roles of abnormal Ca2+ signaling in both atrial and ventricular arrhythmogenesis. It also seeks to bridge the gap between advances in basic science and development of new therapies. |
| Document Type: | eBook |
| File Description: | image/jpeg |
| Language: | English |
| ISBN: | 978-2-88919-874-0 |
| ISSN: | 1664-8714 |
| Relation: | Frontiers Research Topics |
| DOI: | 10.3389/978-2-88919-874-0 |
| Access URL: | https://directory.doabooks.org/handle/20.500.12854/42564 http://www.frontiersin.org/books/Ca2_Signaling_and_Heart_Rhythm/931 http://journal.frontiersin.org/researchtopic/2578/ca2-signaling-and-heart-rhythm |
| Rights: | Attribution 4.0 International open access URL: http://purl.org/coar/access_right/c_abf2 URL: https://creativecommons.org/licenses/by/4.0/ |
| Notes: | 18261 |
| Accession Number: | edsdob.20.500.12854.42564 |
| Database: | Directory of Open Access Books |
| ISBN: | 9782889198740 |
|---|---|
| ISSN: | 16648714 |
| DOI: | 10.3389/978-2-88919-874-0 |
| Language: | English |