The Role of Natural Products on Diabetes Mellitus Treatment
| Title: | The Role of Natural Products on Diabetes Mellitus Treatment |
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| Contributors: | Aragon Novoa, Diana Marcela, Silva, Fátima Regina Mena Barreto |
| Publisher Information: | MDPI - Multidisciplinary Digital Publishing Institute, 2024. |
| Publication Year: | 2024 |
| Subject Terms: | narirutin, naringenin rutinoside, isonaringin, molecular docking, mechanism of action, enzyme, receptors, diabetes mellitus, neurotoxicity, curcumin nanoparticle, zinc oxide nanoparticle, metformin, inflammation, oxidative stress, apoptosis, acarbose, combination approach, Ecklonia radiata, fucoidan, type 2 diabetes management, Lavandula pedunculata (Mill.) Cav., Punica granatum L., Trigonella foenum-graecum L., diabetes, glucose intestinal absorption, oral glucose tolerance test, pregnancy, type 1 diabetes mellitus, beta-cell, insulin, C-peptide, hypoglycemia, n-3 PUFA, placenta, fetus, oleuropein, Mediterranean diet, metabolic syndrome, silymarin, combination therapy, liver steatosis, pre-diabetes, advanced glycation end products, polydatin, salivary gland, type 2, biological products, plants, antioxidants, therapeutics, natural products, phenols, ageing, diabetic cardiomyopathy, mitochondrial longevity, electron transport chain, BGP-15, nicotinic acid, NAD precursor, bioactive molecule, NA/STZ-induced diabetes mellitus, Balanitis aegyptiaca, fruit, seed, aqueous extracts, edible mushroom, insulin resistance, polysaccharide, vitamin D, α-glucosidase, α-amylase, Artemisia absinthium, antioxidant activity, phenolic compounds, hyperglycemia, pancreatic α-amylase, intestinal α-glucosidase, rosinidin, streptozotocin, lipid profile, proinflammatory cytokine, CXCL16, ADAM10, NF-κβ, pancreatic islets, resveratrol, T1D, sweeteners, D-Pinitol, carob fruit, pituitary hormones, type 2 diabetes, Chinese herbal medicine, YH1, gut microbiota, bile acids, elderberry, yarrow, cornelian cherry, bilberry, wild strawberry, rosehip, raspberry, blackberry, stinging nettle, Trigonella foenum-graecum, fenugreek, prediabetes, fasting blood glucose, post-prandial glucose, flavonoid, rutin, antioxidant, lipidosis, flavonoids, polyphenols, patent, marine natural products, Dysidea avara, sesquiterpene-type quinones, avarone, aldose reductase, protein tyrosine phosphatase 1B, dual target inhibitors, Orthosiphon stamineus, GLUT4, anti-oxidant, phytochemicals, Medicine and Nursing |
| More Details: | The utilization of medicinal plants in the treatment of diabetes mellitus (DM) holds significant promise due to their diverse bioactive compounds. These plants have been historically acknowledged for their potential in managing DM and its complications. They often contain secondary metabolites with inherent hypoglycemic properties, aiding in regulating blood glucose levels. Several plants and secondary metabolites have shown effectiveness in improving insulin sensitivity, enhancing glucose uptake, and mitigating the adverse effects associated with DM. For instance, bitter melon (Momordica charantia) contains charantin and polypeptide-p, both known for their hypoglycemic effects. Additionally, fenugreek (Trigonella foenum-graecum) exhibits hypoglycemic properties attributed to the presence of trigonelline and diosgenin.The complex array of bioactive compounds present in medicinal plants offers a multifaceted approach to managing DM. Flavonoids, alkaloids, polyphenols, and terpenoids found in these plants exert antioxidant, anti-inflammatory, and anti-glycation effects, mitigating oxidative stress and inflammation often associated with diabetic complications.This Special Issue highlights the role of natural products in the treatment of DM, including recent patents as well as the effects of characterized extracts and the cellular mechanisms of isolated secondary metabolites in preclinical and clinical studies. |
| Document Type: | eBook |
| File Description: | application/octet-stream |
| Language: | English |
| ISBN: | 978-3-7258-0010-0 978-3-7258-0009-4 |
| DOI: | 10.3390/books978-3-7258-0009-4 |
| Access URL: | https://directory.doabooks.org/handle/20.500.12854/137520 https://mdpi.com/books/pdfview/book/8680 |
| Rights: | Attribution-NonCommercial-NoDerivatives 4.0 International open access URL: http://purl.org/coar/access_right/c_abf2 URL: https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Notes: | ONIX_20240514_9783725800100_122 |
| Accession Number: | edsdob.20.500.12854.137520 |
| Database: | Directory of Open Access Books |
| ISBN: | 9783725800100 9783725800094 |
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| DOI: | 10.3390/books978-3-7258-0009-4 |
| Language: | English |