Ion channels in critical membranes: clustering, cooperativity, and memory effects
| Title: | Ion channels in critical membranes: clustering, cooperativity, and memory effects |
|---|---|
| Authors: | Suma, Antonio, Sigg, Daniel, Gallagher, Seamus, Gonnella, Giuseppe, Carnevale, Vincenzo |
| Publication Year: | 2024 |
| Collection: | Condensed Matter Physics (Other) Quantitative Biology |
| Subject Terms: | Condensed Matter - Soft Condensed Matter, Physics - Biological Physics, Quantitative Biology - Biomolecules |
| More Details: | Much progress has been made in elucidating the inner workings of voltage-gated ion channels, but less understood is the influence of lipid rafts on gating kinetics. Here we propose that state-dependent channel affinity for different lipid species provides a unified explanation for the experimentally observed behaviors of clustering, cooperativity, and hysteresis. We develop models of diffusing lipids and channels engaged in Ising-like interactions to investigate the collective behaviors driven by raft formation in critical membranes close to the demixing transition. The model channels demonstrate lipid-mediated long-range interactions, activation curve steepening, and long-term memory in ionic currents. These behaviors likely play a role in channel-mediated cellular signaling and suggest a universal mechanism for self-organization of biomolecular assemblies. Comment: 14 pages, 6 figures |
| Document Type: | Working Paper |
| Access URL: | http://arxiv.org/abs/2401.07660 |
| Accession Number: | edsarx.2401.07660 |
| Database: | arXiv |
| Description not available. |