High-Sensitivity Iodine Imaging by Combining Spectral CT Technologies

Bibliographic Details
Title:	High-Sensitivity Iodine Imaging by Combining Spectral CT Technologies
Authors:	Tivnan, Matthew, Gang, Grace, Cao, Wenchao, Shapira, Nadav, Noel, Peter B., Stayman, J. Webster
Publication Year:	2021
Collection:	Physics (Other)
Subject Terms:	Physics - Medical Physics, Electrical Engineering and Systems Science - Image and Video Processing
More Details:	Spectral CT offers enhanced material discrimination over single-energy systems and enables quantitative estimation of basis material density images. Water/iodine decomposition in contrast-enhanced CT is one of the most widespread applications of this technology in the clinic. However, low concentrations of iodine can be difficult to estimate accurately, limiting potential clinical applications and/or raising injected contrast agent requirements. We seek high-sensitivity spectral CT system designs which minimize noise in water/iodine density estimates. In this work, we present a model-driven framework for spectral CT system design optimization to maximize material separability. We apply this tool to optimize the sensitivity spectra on a spectral CT test bench using a hybrid design which combines source kVp control and k-edge filtration. Following design optimization, we scanned a water/iodine phantom with the hybrid spectral CT system and performed dose-normalized comparisons to two single-technique designs which use only kVp control or only kedge filtration. The material decomposition results show that the hybrid system reduces both standard deviation and crossmaterial noise correlations compared to the designs where the constituent technologies are used individually.
Document Type:	Working Paper
Access URL:	http://arxiv.org/abs/2103.15735
Accession Number:	edsarx.2103.15735
Database:	arXiv

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RecordInfo	BibRecord: BibEntity: Subjects: – SubjectFull: Physics - Medical Physics Type: general – SubjectFull: Electrical Engineering and Systems Science - Image and Video Processing Type: general Titles: – TitleFull: High-Sensitivity Iodine Imaging by Combining Spectral CT Technologies Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Tivnan, Matthew – PersonEntity: Name: NameFull: Gang, Grace – PersonEntity: Name: NameFull: Cao, Wenchao – PersonEntity: Name: NameFull: Shapira, Nadav – PersonEntity: Name: NameFull: Noel, Peter B. – PersonEntity: Name: NameFull: Stayman, J. Webster IsPartOfRelationships: – BibEntity: Dates: – D: 29 M: 03 Type: published Y: 2021
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