Topological data analysis of C. elegans locomotion and behavior
| Title: | Topological data analysis of C. elegans locomotion and behavior |
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| Authors: | Thomas, Ashleigh, Bates, Kathleen, Elchesen, Alex, Hartsock, Iryna, Lu, Hang, Bubenik, Peter |
| Source: | Front. Artif. Intell. 4:668395 (2021) |
| Publication Year: | 2021 |
| Collection: | Mathematics Quantitative Biology |
| Subject Terms: | Mathematics - Algebraic Topology, Quantitative Biology - Quantitative Methods, 55N31 (Primary), 62R40 (Secondary) |
| More Details: | We apply topological data analysis to the behavior of C. elegans, a widely-studied model organism in biology. In particular, we use topology to produce a quantitative summary of complex behavior which may be applied to high-throughput data. Our methods allow us to distinguish and classify videos from various environmental conditions and we analyze the trade-off between accuracy and interpretability. Furthermore, we present a novel technique for visualizing the outputs of our analysis in terms of the input. Specifically, we use representative cycles of persistent homology to produce synthetic videos of stereotypical behaviors. Comment: 27 pages, 15 figures/tables |
| Document Type: | Working Paper |
| DOI: | 10.3389/frai.2021.668395 |
| Access URL: | http://arxiv.org/abs/2102.09380 |
| Accession Number: | edsarx.2102.09380 |
| Database: | arXiv |
| DOI: | 10.3389/frai.2021.668395 |
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