DIVE: A spatiotemporal progression model of brain pathology in neurodegenerative disorders
| Title: | DIVE: A spatiotemporal progression model of brain pathology in neurodegenerative disorders |
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| Authors: | Marinescu, Razvan V., Eshaghi, Arman, Lorenzi, Marco, Young, Alexandra L., Oxtoby, Neil P., Garbarino, Sara, Crutch, Sebastian J., Alexander, Daniel C. |
| Source: | NeuroImage, Volume 192, 15 May 2019, Pages 166-177 |
| Publication Year: | 2019 |
| Collection: | Computer Science Quantitative Biology Statistics |
| Subject Terms: | Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning, Quantitative Biology - Neurons and Cognition, Quantitative Biology - Quantitative Methods, Statistics - Machine Learning |
| More Details: | Here we present DIVE: Data-driven Inference of Vertexwise Evolution. DIVE is an image-based disease progression model with single-vertex resolution, designed to reconstruct long-term patterns of brain pathology from short-term longitudinal data sets. DIVE clusters vertex-wise biomarker measurements on the cortical surface that have similar temporal dynamics across a patient population, and concurrently estimates an average trajectory of vertex measurements in each cluster. DIVE uniquely outputs a parcellation of the cortex into areas with common progression patterns, leading to a new signature for individual diseases. DIVE further estimates the disease stage and progression speed for every visit of every subject, potentially enhancing stratification for clinical trials or management. On simulated data, DIVE can recover ground truth clusters and their underlying trajectory, provided the average trajectories are sufficiently different between clusters. We demonstrate DIVE on data from two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Dementia Research Centre (DRC), UK, containing patients with Posterior Cortical Atrophy (PCA) as well as typical Alzheimer's disease (tAD). DIVE finds similar spatial patterns of atrophy for tAD subjects in the two independent datasets (ADNI and DRC), and further reveals distinct patterns of pathology in different diseases (tAD vs PCA) and for distinct types of biomarker data: cortical thickness from Magnetic Resonance Imaging (MRI) vs amyloid load from Positron Emission Tomography (PET). Finally, DIVE can be used to estimate a fine-grained spatial distribution of pathology in the brain using any kind of voxelwise or vertexwise measures including Jacobian compression maps, fractional anisotropy (FA) maps from diffusion imaging or other PET measures. DIVE source code is available online: https://github.com/mrazvan22/dive Comment: 24 pages, 5 figures, 2 tables, 1 algorithm |
| Document Type: | Working Paper |
| DOI: | 10.1016/j.neuroimage.2019.02.053 |
| Access URL: | http://arxiv.org/abs/1901.03553 |
| Accession Number: | edsarx.1901.03553 |
| Database: | arXiv |
| DOI: | 10.1016/j.neuroimage.2019.02.053 |
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