Core-genome scaffold comparison reveals the prevalence that inversion events are associated with pairs of inverted repeats
| Title: | Core-genome scaffold comparison reveals the prevalence that inversion events are associated with pairs of inverted repeats |
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| Authors: | Wang, Dan, Li, Shuaicheng, Guo, Fei, Wang, Lusheng |
| Publication Year: | 2016 |
| Collection: | Computer Science Quantitative Biology |
| Subject Terms: | Quantitative Biology - Genomics, Computer Science - Computational Engineering, Finance, and Science |
| More Details: | Motivation: Genome rearrangement plays an important role in evolutionary biology and has profound impacts on phenotype in organisms ranging from microbes to humans. The mechanisms for genome rearrangement events remain unclear. Lots of comparisons have been conducted among different species. To reveal the mechanisms for rearrangement events, comparison of different individuals/strains within the same species or genus (pan-genomes) is more helpful since they are much closer to each other. Results: We study the mechanism for inversion events via core-genome scaffold comparison of different strains within the same species. We focus on two kinds of bacteria, Pseudomonas aeruginosa and Escherichia coli, and investigate the inversion events among different strains of the same specie. We find an interesting phenomenon that long (larger than 10,000 bp) inversion regions are flanked by a pair of Inverted Repeats (IRs) (with lengths ranging from 385 bp to 27476 bp) which are often Insertion Sequences (ISs).This mechanism can also explain why the breakpoint reuses for inversion events happen. We study the prevalence of the phenomenon and find that it is a major mechanism for inversions. The other observation is that for different rearrangement events such as transposition and inverted block interchange, the two ends of the swapped regions are also associated with repeats so that after the rearrangement operations the two ends of the swapped regions remain unchanged. To our knowledge, this is the first time such a phenomenon is reported for transposition event. Comment: 8 pages, 11 figures |
| Document Type: | Working Paper |
| Access URL: | http://arxiv.org/abs/1608.02375 |
| Accession Number: | edsarx.1608.02375 |
| Database: | arXiv |
| Description not available. |