Bibliographic Details
| Title: |
Cytokine mRNA expression in mouse colon: IL-15 mRNA is overexpressed and is highly sensitive to a fibre-like dietary component (short-chain fructo-oligosaccharides) in an Apcgene manner |
| Authors: |
Bassonga, Euphémie, Forest, Virginie, Pierre, Fabrice, Bornet, Francis, Perrin, Pascale, Meflah, Khaled, Menanteau, Jean |
| Source: |
Cytokine; May 2001, Vol. 14 Issue: 4 p243-246, 4p |
| Abstract: |
On the basis of studies using the Minmouse model of colon carcinogenesis, we have recently proposed that a fibre-like food (short-chain fructo-oligosaccharides, sc-FOS) fermented in the colon may stimulate a mechanism of cancer immunosurveillance. In the present paper, we have investigated the expression of cytokines as potential effector molecules. Interleukin (IL-)4, IL-5, IL-13, IL-15 and interferon (INF)-γ mRNAs were detected by a multi-probe ribonuclease protection assay in C57BL/6J and Minmouse colons. IL-15 mRNA expression was significantly amplified (P=0.01) by the sc-FOS-enriched diet in the colon of Minmice. |
| Database: |
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