Bibliographic Details
| Title: |
Loss of BCL7A Permits IRF4 Transcriptional Activity and Cellular Growth in Multiple Myeloma |
| Authors: |
Chakraborty, Chandraditya, Talluri, Srikanth, Binder, Moritz, Morelli, Eugenio, Mayoral, Jessica Encinas, Derebail, Sanika, Aktas Samur, Anil, Epstein, Charles, Anderson, Kenneth C., Shammas, Masood, Samur, Mehmet K., Fulciniti, Mariateresa, Munshi, Nikhil C. |
| Source: |
Blood; 20250101, Issue: Preprints |
| Abstract: |
•Frequent non-coding mutations and loss of expression of BCL7A in multiple myeloma (MM) cells suggest its role as a tumor suppressor in MM.•BCL7A binds to IRF4, inhibiting its DNA binding ability in MM cells, and sequesters IRF4, impairing its transcriptional program in MM. |
| Database: |
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