| Title: |
NAD+metabolism restriction boosts high-dose melphalan efficacy in patients with multiple myeloma |
| Authors: |
Soncini, Debora, Becherini, Pamela, Ladisa, Francesco, Ravera, Silvia, Chedere, Adithya, Gelli, Elisa, Giorgetti, Giulia, Martinuzzi, Claudia, Piacente, Francesco, Mastracci, Luca, Veneziano, Claudia, Santamaria, Gianluca, Monacelli, Fiammetta, Ghanem, Moustafa S., Cagnetta, Antonia, Guolo, Fabio, Garibotto, Matteo, Aquino, Sara, Passalaqua, Mario, Bruzzone, Santina, Bellotti, Axel, Duchosal, Michel A., Nahimana, Aimable, Angelucci, Emanuele, Nagasuma, Chandra, Nencioni, Alessio, Lemoli, Roberto Massimo, Cea, Michele |
| Source: |
Blood Advances; March 2025, Vol. 9 Issue: 5 p1024-1039, 16p |
| Abstract: |
•Novel insights in NAD+metabolism of MM overcome the therapeutic limitations of previous NAD+depletion strategy through NAMPT inhibitors.•Dual NAMPT/NAPRT inhibition compromise oxidative homeostasis, heightening melphalan sensitivity, suggesting a potential combination therapy. |
| Database: |
Supplemental Index |
