Bibliographic Details
| Title: |
Building pangenome graphs |
| Authors: |
Garrison, Erik, Guarracino, Andrea, Heumos, Simon, Villani, Flavia, Bao, Zhigui, Tattini, Lorenzo, Hagmann, Jörg, Vorbrugg, Sebastian, Marco-Sola, Santiago, Kubica, Christian, Ashbrook, David G., Thorell, Kaisa, Rusholme-Pilcher, Rachel L., Liti, Gianni, Rudbeck, Emilio, Golicz, Agnieszka A., Nahnsen, Sven, Yang, Zuyu, Mwaniki, Moses Njagi, Nobrega, Franklin L., Wu, Yi, Chen, Hao, de Ligt, Joep, Sudmant, Peter H., Huang, Sanwen, Weigel, Detlef, Soranzo, Nicole, Colonna, Vincenza, Williams, Robert W., Prins, Pjotr |
| Source: |
Nature Methods; November 2024, Vol. 21 Issue: 11 p2008-2012, 5p |
| Abstract: |
Pangenome graphs can represent all variation between multiple reference genomes, but current approaches to build them exclude complex sequences or are based upon a single reference. In response, we developed the PanGenome Graph Builder, a pipeline for constructing pangenome graphs without bias or exclusion. The PanGenome Graph Builder uses all-to-all alignments to build a variation graph in which we can identify variation, measure conservation, detect recombination events and infer phylogenetic relationships. |
| Database: |
Supplemental Index |
