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Role of apelin-13 in ischemic stroke under high-fat diet-induced metabolic disturbances at middle- age

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Title: Role of apelin-13 in ischemic stroke under high-fat diet-induced metabolic disturbances at middle- age
Authors: Petrault, Maud, Petrault, Olivier, Ki, Vincent Berezows, Gele, Patrick, Bastide, Michèle
Source: Cerebral Circulation - Cognition and Behavior; January 2024, Vol. 6 Issue: 1, Number 1 Supplement 1
Abstract: Visceral fat gain and the progressive onset of metabolic disorders in middle-aged mice induce alteration of the cerebral vascular tree in association with mild cognitive impairment. This precipitates stroke risk and might prompt the middle-aged population to cognitive decline. In this context, an endogenous peptide named apelin-13 and its receptor APJ are suspected to link metabolic disorders at middle age to the consequences of ischemic stroke on brain tissue, as well as vasomotor and cognitive functions. Apelin-13 induces neuroprotection after experimental ischemic stroke, but this action has not been examined under metabolic disturbances. The aim of our study is to evaluate the role of apelin-13 as a new therapeutic target in ischemic stroke under high-fat diet-induced metabolic disturbances at middle-age.
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  Data: Role of apelin-13 in ischemic stroke under high-fat diet-induced metabolic disturbances at middle- age
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  Data: Cerebral Circulation - Cognition and Behavior; January 2024, Vol. 6 Issue: 1, Number 1 Supplement 1
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Visceral fat gain and the progressive onset of metabolic disorders in middle-aged mice induce alteration of the cerebral vascular tree in association with mild cognitive impairment. This precipitates stroke risk and might prompt the middle-aged population to cognitive decline. In this context, an endogenous peptide named apelin-13 and its receptor APJ are suspected to link metabolic disorders at middle age to the consequences of ischemic stroke on brain tissue, as well as vasomotor and cognitive functions. Apelin-13 induces neuroprotection after experimental ischemic stroke, but this action has not been examined under metabolic disturbances. The aim of our study is to evaluate the role of apelin-13 as a new therapeutic target in ischemic stroke under high-fat diet-induced metabolic disturbances at middle-age.
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      – Type: doi
        Value: 10.1016/j.cccb.2024.100244
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      – Code: eng
        Text: English
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      – TitleFull: Role of apelin-13 in ischemic stroke under high-fat diet-induced metabolic disturbances at middle- age
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            NameFull: Petrault, Maud
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            – D: 01
              M: 01
              Text: January 2024
              Type: published
              Y: 2024
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              Value: 6
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              Value: 1, Number 1 Supplement 1
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            – TitleFull: Cerebral Circulation - Cognition and Behavior
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