Bibliographic Details
| Title: |
Role of apelin-13 in ischemic stroke under high-fat diet-induced metabolic disturbances at middle- age |
| Authors: |
Petrault, Maud, Petrault, Olivier, Ki, Vincent Berezows, Gele, Patrick, Bastide, Michèle |
| Source: |
Cerebral Circulation - Cognition and Behavior; January 2024, Vol. 6 Issue: 1, Number 1 Supplement 1 |
| Abstract: |
Visceral fat gain and the progressive onset of metabolic disorders in middle-aged mice induce alteration of the cerebral vascular tree in association with mild cognitive impairment. This precipitates stroke risk and might prompt the middle-aged population to cognitive decline. In this context, an endogenous peptide named apelin-13 and its receptor APJ are suspected to link metabolic disorders at middle age to the consequences of ischemic stroke on brain tissue, as well as vasomotor and cognitive functions. Apelin-13 induces neuroprotection after experimental ischemic stroke, but this action has not been examined under metabolic disturbances. The aim of our study is to evaluate the role of apelin-13 as a new therapeutic target in ischemic stroke under high-fat diet-induced metabolic disturbances at middle-age. |
| Database: |
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