Bibliographic Details
| Title: |
Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma |
| Authors: |
Fischer, Luise, Grieb, Nora, Born, Patrick, Weiss, Ronald, Seiffert, Sabine, Boldt, Andreas, Fricke, Stephan, Franz, Paul, Heyn, Simone, Kubasch, Anne Sophie, Baber, Ronny, Weidner, Heike, Wang, Song Yau, Bach, Enrica, Hoffmann, Sandra, Ussmann, Jule, Kirchberg, Janine, Hell, Saskia, Schwind, Sebastian, Metzeler, Klaus H., Herling, Marco, Jentzsch, Madlen, Franke, Georg-Nikolaus, Sack, Ulrich, Reiche, Kristin, Köhl, Ulrike, Platzbecker, Uwe, Vucinic, Vladan, Merz, Maximilian |
| Source: |
Leukemia; 20240101, Issue: Preprints p1-11, 11p |
| Abstract: |
B-cell maturation antigen (BCMA)-targeting chimeric antigen receptor (CAR) T cells revolutionized the treatment of relapsed/refractory multiple myeloma (RRMM). However, data on cellular (CAR) T cell dynamics and the association with response, resistance or the occurrence of cytokine release syndrome (CRS) are limited. Therefore, we performed a comprehensive flow cytometry analysis of 27 RRMM patients treated with Idecabtagene vicleucel (Ide-cel) to assess the expansion capacity, persistence and effects on bystander cells of BCMA-targeting CAR T cells. Additionally, we addressed side effects, like cytokine release syndrome (CRS) and cytopenia. Our results show that in vivo expansion of CD8+CAR T cells is correlated to response, however persistence is not essential for durable remission in RRMM patients. In addition, our data provide evidence, that an increased fraction of CD8+T cells at day of leukapheresis in combination with successful lymphodepletion positively influence the outcome. We show that patients at risk for higher-grade CRS can be identified already prior to lymphodepletion. Our extensive characterization contributes to a better understanding of the dynamics and effects of BCMA-targeting CAR T cells, in order to predict the response of individual patients as well as side effects, which can be counteracted at an early stage or even prevented. |
| Database: |
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