Bibliographic Details
| Title: |
Impact of Omicron BA.1 infection on BA.4/5 immunity in transplant recipients |
| Authors: |
Ferreira, Victor H., Hu, Queenie, Kurtesi, Alexandra, Solera, Javier T., Ierullo, Matthew, Gingras, Anne-Claude, Kumar, Deepali, Humar, Atul |
| Source: |
American journal of transplantation; February 2023, Vol. 23 Issue: 2 p278-283, 6p |
| Abstract: |
Mutations in the spike protein of SARS-CoV-2 have allowed Omicron subvariants to escape neutralizing antibodies. The degree to which this occurs in transplant recipients is poorly understood. We measured BA.4/5 cross-neutralizing responses in 75 mostly vaccinated transplant recipients who recovered from BA.1 infection. Sera were collected at 1 and 6 months post-BA.1 infection, and a lentivirus pseudovirus neutralization assay was performed using spike constructs corresponding to BA.1 and BA.4/5. Uninfected immunized transplant recipients and health care worker controls were used for comparison. Following BA.1 infection, the proportion of transplant recipients with neutralizing antibody responses was 88.0% (66/75) against BA.1 and 69.3% (52/75) against BA.4/5 (P= .005). The neutralization level against BA.4/5 was approximately 17-fold lower than that against BA.1 (IQR 10.6- to 45.1-fold lower, P< .0001). BA.4/5 responses declined over time and by ≥0.5 log10(approximately 3-fold) in almost half of the patients by 6 months. BA.4/5-neutralizing antibody titers in transplant recipients with breakthrough BA.1 infection were similar to those in immunized health care workers but significantly lower than those in uninfected triple-vaccinated transplant recipients. These results provide evidence that transplant recipients are at ongoing risk for BA.4/5 infection despite vaccination and prior Omicron strain infection, and additional mitigation strategies may be required to prevent severe disease in this cohort. |
| Database: |
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