Distinct Profiles of DNA Repair Activity Define Favorable-risk Prostate Cancer Subtypes With Divergent Outcome
| Title: | Distinct Profiles of DNA Repair Activity Define Favorable-risk Prostate Cancer Subtypes With Divergent Outcome |
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| Authors: | Swami, Nishwant, Nguyen, Tiffany, Ogobuiro, Ifeanyichukwu, Abramowitz, Matthew, Chipidza, Fallon, Davicioni, Elai, Meiyappan, Karthik, Pra, Alan Dal, Nguyen, Paul L., Pollack, Alan, Punnen, Sanoj, Mahal, Brandon A., Alshalalfa, Mohammed |
| Source: | Clinical Genitourinary Cancer; 20220101, Issue: Preprints |
| Abstract: | •This study first shows that high DNA repair activity is associated with high-risk prostate cancer.•Within low-risk prostate tumors, higher DNA repair activity is associated with poor outcome.•Within low-risk prostate patients who are candidates for active surveillance, high DNA repair activity defines a molecularly and clinically distinct subtype. |
| Database: | Supplemental Index |
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