miRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders

Bibliographic Details
Title: miRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders
Authors: Tsermpini, Evangelia Eirini, Kalogirou, Christina I., Kyriakopoulos, George C., Patrinos, George P., Stathopoulos, Constantinos
Source: The Pharmacogenomics Journal; July 2022, Vol. 22 Issue: 4 p211-222, 12p
Abstract: The heterogeneity of psychiatric disorders and the lack of reliable biomarkers for prediction and treatments follow-up pose difficulties towards recognition and understanding of the molecular basis of psychiatric diseases. However, several studies based on NGS approaches have shown that miRNAs could regulate gene expression during onset and disease progression and could serve as potential diagnostic and pharmacogenomics biomarkers during treatment. We provide herein a detailed overview of circulating miRNAs and their expression profiles as biomarkers in schizophrenia, bipolar disorder and major depressive disorder and their role in response to specific treatments. Bioinformatics analysis of miR-34a, miR-106, miR-134 and miR-132, which are common among SZ, BD and MDD patients, showed brain enrichment and involvement in the modulation of critical signaling pathways, which are often deregulated in psychiatric disorders. We propose that specific miRNAs support accurate diagnosis and effective precision treatment of psychiatric disorders.
Database: Supplemental Index
More Details
ISSN:1470269X
14731150
DOI:10.1038/s41397-022-00283-7
Published in:The Pharmacogenomics Journal
Language:English