Bibliographic Details
| Title: |
Abstract P244: Serum Uric Acid Level is A Predictor of Nonalcoholic Fatty Liver Disease in an Apparently Healthy Population |
| Authors: |
Baena, Cristina P, Martins, Grasiele L, Leite, Mariana F, Haagsma, Ariele B, de Paiva, Clara I, Kallaur, Guilherme R, Nogueira, Andre M, Simao, Camila C, Cavalli, Camila, Goss, Daniele R, Junior, Paulo A |
| Source: |
Circulation (Ovid); March 2019, Vol. 139 Issue: Supplement 1 pAP244-AP244, 1p |
| Abstract: |
Background:Nonalcoholic Fatty Liver Disease (NAFLD) is the most frequent hepatic abnormality in the western countries and commonly asymptomatic. Known risk factors for the disease are obesity, type 2 diabetes, hypertension and dyslipidemia. Serum Uric Acid levels (SUA) has been associated with a variety of cardiometabolic disorders. Yet the relationship between NAFLD and SUA is less known.Hypothesis:We assessed the hypothesis that there is an association between SUA levels with NAFLD in an apparently healthy population in Brazil. Materials andMethods:A cross-sectional study was conducted among 2.660 adult Brazilians who underwent to a medical check-up at Marcelino Champagnat Hospital in Curitiba/PR. Sociodemographic, anthropometric and laboratory evaluations were conducted, including abdominal ultrasonography. NAFLD was diagnosed by abdominal ultrasound, with evidence of contrast between the liver and renal parenchyma. Individuals with history of significant alcohol consumption (intake superior to 140g/week for men and 70g/week for women) or using hipouricemic medications were excluded from the analysis. Binary logistic regression models were built to test the impact of SUA levels on NAFLD by sex. Adjustments were subsequently made by age, fasting glucose, body mass index, hypertension, dyslipidemia and smoking status to test the independence of SUA in association with NAFLD.Results:We included 1.329 men (46.1±8.5 years) and 351 women (46.3±8.2 years) in the final analysis. Prevalence of NAFLD were 35.6% and 38.7% for men and women, respectively (p<0.001). Mean SUA levels were significantly higher in subjects with NAFLD (6.52±1.30mg/dL vs 5.51±1.41 mg/dL) in men and ( 6.36±1.34 mg/dL vs 5.53 ±1.28 mg/dL) in women (p<0.001 for both). Crude models for NAFLD by unit of SUA yielded OR of 1.69 (CI 95% 1.53-1.86) and 1.61 (CI 95% 1.33-1.94) for men and women, respectively. Fully adjusted models showed OR of 1.43 (CI 95% 1.27-1.62) and 1.48 (CI 95% 1.17-1.88), for men and women, respectively.Conclusion:SUA levels are independently associated with NAFLD in an apparently healthy population. Future studies should explore the benefits of lowering SUA levels on NAFLD prevention and potential mechanisms of this association. |
| Database: |
Supplemental Index |
