Bibliographic Details
| Title: |
Humoral Immunity to Commensal Oral Bacteria in Human Infants: Salivary Antibodies Reactive with Actinomyces naeslundiiGenospecies 1 and 2 during Colonization |
| Authors: |
Cole, Michael F., Bryan, Stacey, Evans, Mishell K., Pearce, Cheryl L., Sheridan, Michael J., Sura, Patricia A., Wientzen, Raoul, Bowden, George H. W. |
| Source: |
Infection and Immunity; September 1998, Vol. 66 Issue: 9 p4283-4289, 7p |
| Abstract: |
ABSTRACTThe secretory immune response in saliva to colonization byActinomyces naeslundiigenospecies 1 and 2 was studied in 10 human infants from birth to 2 years of age. Actinomycesspecies were not recovered from the mouths of the infants until approximately 4 months after the eruption of teeth. However, low levels of secretory immunoglobulin A1 (SIgA1) and SIgA2 antibodies reactive with whole cells of A. naeslundiigenospecies 1 and 2 were detected within the first month after birth. Although there was a fivefold increase in the concentration of SIgA between birth and age 2 years, there were no differences between the concentrations of SIgA1 and SIgA2 antibodies reactive with A. naeslundiigenospecies 1 and 2 over this period. When the concentrations of SIgA1 and SIgA2 antibodies reactive with whole cells of A. naeslundiigenospecies 1 and 2 were normalized to the concentrations of SIgA1 and SIgA2 in saliva, the A. naeslundiigenospecies 1- and 2-reactive SIgA1 and SIgA2 antibodies showed a significant decrease from birth to 2 years of age. The fine specificities of A. naeslundiigenospecies 1- and 2-reactive SIgA1 and SIgA2 antibodies were examined by Western blotting of envelope proteins. Similarities in the molecular masses of proteins recognized by SIgA1 and SIgA2 antibodies, both within and between subjects over time, were examined by cluster analysis and showed considerable variability. Taken overall, our data suggest that among the mechanismsActinomycesspecies employ to persist in the oral cavity are the induction of a limited immune response and clonal replacement with strains differing in their antigen profiles. |
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