Bibliographic Details
| Title: |
LRIKinteracts with the Ku70–Ku80 heterodimer enhancing the efficiency of NHEJ repair |
| Authors: |
Wang, Dan, Zhou, Zheng, Wu, Erzhong, Ouyang, Can, Wei, Guifeng, Wang, Yunfei, He, Dandan, Cui, Ya, Zhang, Dongdong, Chen, Xiaomin, Reed, Simon H., Luo, Jianjun, Chen, Runsheng |
| Source: |
Cell Death and Differentiation; December 2020, Vol. 27 Issue: 12 p3337-3353, 17p |
| Abstract: |
Despite recent advances in our understanding of the function of long noncoding RNAs (lncRNAs), their roles and functions in DNA repair pathways remain poorly understood. By screening a panel of uncharacterized lncRNAs to identify those whose transcription is induced by double-strand breaks (DSBs), we identified a novel lncRNA referred to as LRIKthat interacts with Ku, which enhances the ability of the Ku heterodimer to detect the presence of DSBs. Here, we show that depletion of LRIKgenerates significantly enhanced sensitivity to DSB-inducing agents and reduced DSB repair efficiency. In response to DSBs, LRIKenhances the recruitment of repair factors at DSB sites and facilitates ?H2AX signaling. Our results demonstrate that LRIKis necessary for efficient repairing DSBs via nonhomologous end-joining pathway. |
| Database: |
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