| Title: |
PENTOSAN POLYSULFATE TREATMENT REDUCES CYCLOSPORINE-INDUCED NEPHROPATHY IN SALT-DEPLETED RATS1 |
| Authors: |
Schwedler, Susanne B., Bobadilla, Norma, Striker, Liliane J., Vaamonde, Carlos A., Herrera-Acosta, Jaime, Striker, Gary E. |
| Source: |
Transplantation; November 1999, Vol. 68 Issue: 10 p1583-1588, 6p |
| Abstract: |
Long-term cyclosporine (CsA) treatment leads to a decreased glomerular filtration rate, hyalinosis of afferent arterioles, and striped cortical tubulo-interstitial fibrosis. We showed previously that pentosan polysulfate (SP54) prevented the development of microvascular and interstitial lesions in mouse models of progressive glomerulosclerosis. In this study, we examined the effect of pentosan polysulfate on the development of CsA nephropathy. |
| Database: |
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