Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathioneThis article is a US Government work and, as such, is in the public domain in the United States of America.

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Title:	Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathioneThis article is a US Government work and, as such, is in the public domain in the United States of America.
Authors:	Berkeley, Lorelle I., Cohen, Jonathan F., Crankshaw, Daune L., Shirota, Frances N.
Source:	Journal of Biochemical and Molecular Toxicology (Formerly Journal of Biochemical Toxicology); 2003, Vol. 17 Issue: 2 p95-97, 3p
Abstract:	L-Cysteine-glutathione disulfide, a ubiquitous substance present in mammalian cells, was shown to be highly effective in protecting mice against acetaminophen-induced hepatotoxicity. Since the corresponding D-cysteine-glutathione disulfide was totally ineffective in this regard, an enzymatic mechanism that provides glutathione directly to cells is postulated. © 2003 Wiley Periodicals, Inc. J Biochem Mol Toxicol 17:9597, 2003; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/jbt.10069
Database:	Supplemental Index

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ISSN:	10956670 10990461
DOI:	10.1002/jbt.10069
Published in:	Journal of Biochemical and Molecular Toxicology (Formerly Journal of Biochemical Toxicology)
Language:	English