| Title: |
Evidence for Testicular Impairment After Long-Term Treatment with a Luteinizing Hormone-Releasing Hormone Agonist in Elderly Men |
| Authors: |
Decensi, Andrea U., Guarneri, Domenico, Marroni, Paola, Cristina, Liborio Di, Paganuzzi, Michela, Boccardo, Francesco |
| Source: |
The Journal of Urology; November 1989, Vol. 142 Issue: 5 p1235-1238, 4p |
| Abstract: |
Testicular responsiveness to 5,000IU of human chorionic gonadotropin was evaluated in 14 patients with prostate cancer who were being treated with a slow-release luteinizing hormone releasing hormone agonist for a median of 21 months. Serum testosterone response to human chorionic gonadotropin was markedly reduced in most patients, with the median level increasing from 0.25 to 1.65nmol. per l. A second human chorionic gonadotropin test was repeated later in 5 patients who had been off treatment for a median of 6 months. Median serum testosterone levels increased to a maximum of 2.6nmol. per l. compared to 28.2nmol. per l. in an age-matched control group (p equals 0.008). Therefore, we conclude that long-term treatment with luteinizing hormone releasing hormone agonists in elderly men leads to gonadal impairment that may not be as reversible as generally suggested. (J. Urol., 142: 1235-1238, 1989) |
| Database: |
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