| Title: |
Role of GABA in the extraocular motor nuclei of the cat: A postembedding immunocytochemical study |
| Authors: |
de la Cruz, R.R., Pastor, A.M., Martínez-Guijarro, F.J., López-García, C., Delgado-García, J.M. |
| Source: |
Neuroscience; December 1992, Vol. 51 Issue: 4 p911-929, 19p |
| Abstract: |
The GABAergic innervation of the extraocular motor nuclei in the cat was evaluated using postembedding immunocytochemical techniques. The characterization of GABA-immunoreactive terminals in the oculomotor nucleus was carried out at the light and electron microscopic levels. GABA immunopositive puncta suggestive of boutons were abundant in semithin sections throughout the oculomotor nucleus, and were found in close apposition to somata and dendrites. Ultrathin sections revealed an extensive and dense distribution of GABA-immunoreactive synaptic endings that established contacts with the perikarya and proximal dendrites of motoneurons and were also abundant in the surrounding neuropil. GABAergic boutons were characterized by the presence of numerous mitochondria, pleiomorphic vesicles and multiple small symmetrical synaptic contacts. The trochlear nucleus exhibited the highest density of GABAergic terminations. In contrast, scarce GABA immunostaining was associated with the motoneurons and internuclear neurons of the abducens nucleus. |
| Database: |
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