Bibliographic Details
| Title: |
A meta-analysis of the risk of total cardiovascular events of isosmolar iodixanol compared with low-osmolar contrast media. |
| Authors: |
Bu-Chun Zhang, Qjang Wu, Cheng Wang, Dong-Ye Li, Zhi-Rong Wang |
| Source: |
Journal of Cardiology; Mar/Apr2014, Vol. 62 Issue 3/4, p260-268, 9p |
| Abstract: |
Background: The iso-osmolar contrast agent iodixanol may be associated with a lower incidence of cardiac events than low-osmolar contrast media (LOCM), but previous trials have yielded mixed results. Objective: To compare the risk of total cardiovascular events of the iso-osmolar contrast medium, iodixanol, to LOCM. Methods: Medical literature databases were searched to identify comparisons between iodixanol and LOCM with cardiovascular events as a primary endpoint. A random-effects model was used to obtain pooled odds ratio (OR) for within-hospital and 30-day events. Results: A total of 2 prospective cross-sectional studies and 11 randomized controlled trials (RCTs) (covering 6859 subjects) met our criteria. There was no significant difference in the incidence of within-hospital and 30-day cardiovascular events when iodixanol was compared with LOCM, with pooled OR of 0.72 (95% CI 0.49-1.06, p = 0.09) and 1.19 (95% CI 0.70-2.02, p = 0.53), respectively. Subgroup analysis showed no relative difference when iodixanol was compared with ioxaglate (OR = 0.92, 95% CI 0.50-1.70, p = 0.80) and iohexol (OR = 0.75, 95% CI 0.48-1.17, p = 0.21). However, a reduction in the within-hospital cardiovascular events was observed when iodixanol was compared with LOCM in the RCT subgroup (OR = 0.65, 95% CI 0.44-0.96, p = 0.03). Sensitivity analyses revealed that three studies had a strong impact on the association of within-hospital cardiovascular events between iodixanol and LOCM. Meta-regression analysis failed to account for heterogeneity. No publication bias was detected. Conclusions: This meta-analysis demonstrates that there is no conclusive evidence that iodixanol is superior to LOCM overall with regard to fewer cardiovascular events. [ABSTRACT FROM AUTHOR] |
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| Database: |
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