Bibliographic Details
| Title: |
Predictors of Exercise-Induced Oxygen Desaturation in Systemic Sclerosis Patients With Interstitial Lung Disease. |
| Authors: |
Fujiko Someya, Naoki Mugii, Minoru Hasegawa, Tetsutarou Yahata, Takao Nakagawa |
| Source: |
Respiratory Care; Jan2014, Vol. 59 Issue 1, p75-80, 6p |
| Subject Terms: |
ACTIVE oxygen in the body, CHI-squared test, ECHOCARDIOGRAPHY, EXERCISE, INTERSTITIAL lung diseases, OXYGEN, RESPIRATORY measurements, PULMONARY function tests, SYSTEMIC scleroderma, T-test (Statistics), LOGISTIC regression analysis, VITAL capacity (Respiration), RECEIVER operating characteristic curves, DATA analysis software, RESPIRATORY mechanics, DESCRIPTIVE statistics |
| Abstract: |
BACKGROUND: The diffusion capacity of the lung for carbon monoxide (DLCO) is a good marker of disease severity in patients with idiopathic interstitial pneumonia, and is associated with oxygen saturation; however, little is known about DLCO in systemic sclerosis patients with interstitial lung disease. We studied potential predictors of exercise-induced oxygen desaturation in patients with systemic sclerosis. METHODS: Data were collected prospectively from 80 of 110 consecutive systemic sclerosis patients with normal oxygen saturation (> 95%) at rest, who could perform the 6-min walk test without physical discomfort, including leg pain. Pulmonary function tests and echocardiography were collected from all subjects. RESULTS: Thirty subjects showed a ≥ 4% decline in oxygen saturation during the 6-min walk test (desaturation group). The other subjects were assigned to the normoxic group. The percent-of-predicted values for FVC, FEV1, total lung capacity, DLCO, and DLCO/alveolar volume were lower, and FEV1/FVC was higher, in the desaturation group. Logistic regression analysis showed the percent-of-predicted DLCO as a highly accurate predictor of exercise-induced oxygen desaturation: the area under the receiver operating characteristic curve was 0.92 (cutoff point 56.3%, sensitivity 0.83, specificity 0.86). Five subjects over the cutoff point of the percent-of-predicted DLCO in the desaturation group could not be distinguished from the normoxic subjects with the lung-volume measurements or right-ventricular systolic pressure. CONCLUSIONS: The factor underlying exercise-induced oxygen desaturation appeared to be reduced percent-of-predicted DLCO, which was useful as a predictor in over 80% of the subjects. [ABSTRACT FROM AUTHOR] |
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| Database: |
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