Bibliographic Details
| Title: |
Deformation Based Morphometry Analysis of Serial Magnetic Resonance Images of Mouse Brains. |
| Authors: |
Maheswaran, Satheesh, Barjat, Hervé, Bate, Simon, Hartkens, Thomas, Hill, Derek L. G., James, Michael F., Tilling, Lorna, Upton, Neil, Hajnal, Jo, Rueckert, Daniel, Pluim, Josien P. W., Likar, Boštjan, Gerritsen, Frans A. |
| Source: |
Biomedical Image Registration; 2006, p58-65, 8p |
| Abstract: |
Deformation based morphometry is used to detect differences in in-vivo Magnetic Resonance Image (MRI) of the mouse brain obtained from two transgenic strains: TASTPM mice that over-express proteins associated with Alzheimer’s disease, and wild-type mice. MRI was carried out at four time points. We compare two different methods to detect group differences in the longitudinal and cross-sectional data. Both methods are based on non-rigid registration of the images to a mouse brain atlas. The whole brain volume measurements on 27 TASTPM and wild-type animals are reproducible to within 0.4% of whole brain volume. The agreement between different methods for measuring volumes in a serial study is shown. The ability to quantify changes in growth between strains in whole brain, hippocampus and cerebral cortex is demonstrated. [ABSTRACT FROM AUTHOR] |
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| Database: |
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