Bibliographic Details
| Title: |
Anti-tumor effect of proteasome inhibitor on canine urothelial carcinoma. |
| Authors: |
Yuka KODERA, Takaaki IGUCHI, Daiki KATO, Namiko IKEDA, Masahiro SHINADA, Susumu AOKI, Kyoka SOGA, Toshio LI, Ryosuke OHATA, Shoma KOSEKI, Hayato SHIBAHARA, Yosuke TAKAHASHI, Yuko HASHIMOTO, Ryohei NISHIMURA, Takayuki NAKAGAWA |
| Source: |
Journal of Veterinary Medical Science; 2024, Vol. 86 Issue 9, p961-965, 5p |
| Subject Terms: |
PROTEASOME inhibitors, TRANSITIONAL cell carcinoma, PROTEOLYSIS, CELL growth, CELL lines, BORTEZOMIB |
| Abstract: |
Canine urothelial carcinoma (cUC) is one of the most malignant tumors affecting dogs; however, its proliferative mechanism is yet to be fully elucidated. The ubiquitin-proteasome system (UPS) is an important metabolic pathway regulating protein degradation, and its dysfunction leads to apoptosis. We investigated the antitumor effect of the proteasome inhibitor bortezomib, which blocks the UPS. Bortezomib inhibited cell growth in cUC cell lines by inducing apoptosis in vitro. These findings suggest the potential of bortezomib as a novel therapeutic drug for dogs with cUC. [ABSTRACT FROM AUTHOR] |
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| Database: |
Supplemental Index |
