Bibliographic Details
| Title: |
Elevated preoperative serum interleukin-6 level is predictive for worse postoperative outcome after soft tissue sarcoma surgery. |
| Authors: |
van der Laan, P., van der Graaf, W.T.A., Reijers, S.J.M., Schrage, Y.M., Hendriks, J.J.H., Haas, R.L., van den Broek, D., Steeghs, N., van Houdt, W.J. |
| Source: |
European Journal of Surgical Oncology; Sep2023, Vol. 49 Issue 9, pN.PAG-N.PAG, 1p |
| Subject Terms: |
SARCOMA, LEUCOCYTES, INTERLEUKIN-6, PATIENT readmissions, POSTOPERATIVE period |
| Abstract: |
The pro-inflammatory cytokine interleukin-6 (IL-6) plays a role in cancer development and progression, but research into the predictive value of IL-6 on postoperative outcome in soft tissue sarcoma (STS) is scarce. The purpose of this study is to investigate the predictive value of serum IL-6 level for the achievement of assumed (post)operative outcome after STS surgery, the so-called textbook outcome. Preoperative IL-6 serum levels were collected in all patients with a STS at first presentation between February 2020 and November 2021. Textbook outcome was defined as a R0 resection, no complications, no blood transfusions, no reoperation within the postoperative period, no prolonged hospital stay, no hospital readmission within 90-days, and no mortality within 90-days. Factors associated with textbook outcome were determined by multivariable analysis. Among 118 patients with primary, non-metastatic STS, 35.6% achieved a textbook outcome. Univariate analysis showed that smaller tumor size (p = 0.026), lower tumor grade (p = 0.006), normal hemoglobin (Hb, p = 0.044), normal white blood cell (WBC) count (p = 0.018), normal C-reactive protein (CRP) serum level (p = 0.002) and normal IL-6 serum level (p = 1.5 × 10−5) were associated with achieving textbook outcome after surgery. Multivariable analysis showed that elevated IL-6 serum level (p = 0.012) was significantly associated with not achieving a textbook outcome. Increased IL-6 serum level is predictive for not achieving a textbook outcome after surgery for primary, non-metastatic STS. [ABSTRACT FROM AUTHOR] |
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| Database: |
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