Bibliographic Details
| Title: |
Berberine enhances chemosensitivity to irinotecan in colon cancer via inhibition of NF-κB. |
| Authors: |
MEILING YU, XUHUI TONG, BENQUAN QI, HONGDANG QU, SHUYING DONG, BINBIN YU, NAIJU ZHANG, NAN TANG, LINGZHI WANG, CUILING ZHANG |
| Source: |
Molecular Medicine Reports; 2014, Vol. 9 Issue 1, p249-254, 6p |
| Subject Terms: |
BERBERINE, COLON cancer, APOPTOSIS, IRINOTECAN, CAMPTOTHECIN, FLUOROURACIL, DOXORUBICIN |
| Abstract: |
Previous studies have shown that irinotecan (CPT-11) impairs chemotherapy-induced apoptosis by activating nuclear factor κ-B (NF-κB) and a number of strategies have been employed to augment chemosensitivity through the suppression of NF-κB activation. Berberine, a botanical alkaloid, was reported to enhance chemosensitivity to 5-fluorouracil and doxorubicin by suppressing NF-κB activation. In the present study, the effect of berberine on CPT-11 induced apoptosis was investigated through the inhibition of NF-κB. Inhibition of NF-κB activation by p65 small interfering RNA was shown to potentiate apoptosis induced by CPT-11. Berberine suppressed CPT-11 induced NF-κB activation in a dose dependent manner and enhanced chemosensitivity to CPT 11 by downregulating NF κB activation of antiapoptotic genes, c-IAP1, c-IAP2, survivin and Bcl xL. The current observations indicate that berberine inhibits NF-κB activation and may be used to enhance CPT-11 induced apoptosis in colon cancer. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
