| Title: |
TGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular doi:10.1186/1756-9966-31-93carcinoma in mice model. |
| Authors: |
Guo-Cai Li, Qing-Hai Ye, Qiong-Zhu Dong, Ning Ren, Hu-Liang Jia, Lun-Xiu Qin |
| Source: |
Journal of Experimental & Clinical Cancer Research (17569966); 2012, Vol. 31 Issue 1, p93-99, 7p, 1 Diagram, 2 Charts, 2 Graphs |
| Subject Terms: |
CANCER invasiveness, LIVER cancer, CELL culture, MESSENGER RNA, CYTOKINES, ONCOLOGY |
| Abstract: |
Background: Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma (HCC) is till unknown. Methods: We detected the in vitro and in vivo expression levels of TGF β1/Smads by Real-time PCR and Western blot in MHCC97-H and MHCC97-L cell lines, which are HCC cell lines and have higher and lower pulmonary metastatic potential respectively. Results: TGF β1 mRNA level in MHCC97-L tumors were higher than that in MHCC97-H tumors, (2.81±1.61 vs. 1.24±0.96, P=0.002), TGF β1 protein level in MHCC97-L tumors were also higher than that in MHCC97-H tumors (1.37±0.95 vs. 0.32±0.22, P<0.001). In addition, the TGF β1 mRNA level positively correlated with pulmonary metastasis, and the relations between TGF β1 and Smads were also found (R2=0.12 and 0.40, respectively). Conclusions: Our results suggest that TGF β/ Smads promote pulmonary metastasis of HCC. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
