| Title: |
Nevirapine-Associated Hepatotoxicity and Rash among HIV-Infected Pregnant Women in Kenya. |
| Authors: |
Peters, Philip J., Polle, Nicholas, Zeh, Clement, Masaba, Rose, Borkowf, Craig B., Oyaro, Boaz, Omolo, Paul, Ogindo, Paul, Ndivo, Richard, Angira, Frank, Lando, Richard, Fowler, Mary Glenn, Weidle, Paul J., Thomas, Timothy K. |
| Source: |
JIAPAC: Journal of the International Association of Physicians in AIDS Care; Mar2012, Vol. 11 Issue 2, p142-149, 8p |
| Abstract: |
Background: Few studies have evaluated the risk of nevirapine (NVP)-associated hepatotoxicity among HIV-infected pregnant women with a CD4 count ≥250 cells/mm3. Methods: We enrolled HIV-infected pregnant Kenyan women who initiated triple antiretroviral therapy (ART) at 34 weeks gestation. We compared the rates of severe hepatotoxicity (grades 3–4 hepatotoxicity) and rash-associated hepatotoxicity (rash with ≥grade 2 hepatotoxicity) with NVP and nelfinavir (NFV), respectively. Results: We initiated triple ART in 522 pregnant women; severe hepatotoxicity and rash-associated hepatotoxicity occurred in 14 (3%) and 9 (2%) women, respectively. Women who initiated NVP had higher rates of severe hepatotoxicity (5% vs 1%; P = .03) and rash-associated hepatotoxicity (4% vs 0%; P = .003) when compared with NFV. Among women who initiated NVP (n = 254), a baseline CD4 count ≥250 cells/mm3 was not associated with severe hepatotoxicity (5% vs 3%; P = .52) or rash-associated hepatotoxicity (4% vs 3%; P = .69). Conclusion: Nevirapine use but not CD4 count ≥250 cells/mm3 was associated with hepatotoxicity. [ABSTRACT FROM PUBLISHER] |
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| Database: |
Complementary Index |
