Bibliographic Details
| Title: |
Liquid Chromatography-Tandem Mass Spectrometry Determination of the Toxicity and Identification of Fish Species in a Suspected Tetrodotoxin Fish Poisoning. |
| Authors: |
YA-JUNG WU, YING-JU CHENG, HSIAO-CHIN JEN, CHIH-HSIN PAN, TZU-CHUN LIN, SHIN-JUNG LIN, DENG-FWU HWANG |
| Source: |
Journal of Food Protection; May2011, Vol. 74 Issue 5, p789-795, 7p |
| Subject Terms: |
LIQUID chromatography, TANDEM mass spectrometry, TETRODOTOXIN, TOXICITY testing, FISHES |
| Abstract: |
Suspected tetrodotoxin (TTX) poisoning was associated with eating unknown fish in April 2009 in Taiwan. After ingestion of the fish, symptoms of the victim included perioral paresthesia, nausea, vomiting, ataxia, weakness of all limbs, respiration failure, and death within several hours. The toxicity in the remaining fish was determined, with the mice exhibiting symptoms of neurotoxin poisoning. The implicated fish and deceased victim tissues were analyzed for TTX by liquid chromatographytandem mass spectrometry. The urine, bile, cerebrospinal fluid (spinal cord), pleural effusion, and pericardial effusion of the victim contained TTX. In addition, the partial cytochrome b gene of the implicated fish was determined by PCR. The DNA sequence in the partial 465-bp cytochrome b gene identified the implicated fish as Chehmodon patoca (puffer fish). These results indicate that people should avoid eating unknown fish species from fish markets where harvested fish may include toxic species. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Food Protection is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
