| Title: |
Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila. |
| Authors: |
Nicolaï, Laura J. J., Ramaekers, Ariane, Raemaekers, Tim, Drozdzecki, Andrzej, Maus, Alex S., Jiekun Yan, Landgraf, Matthias, Annaert, Wim, Hassan, Bassem A. |
| Source: |
Proceedings of the National Academy of Sciences of the United States of America; 11/23/2010, Vol. 107 Issue 47, p20553-20558, 6p, 4 Color Photographs |
| Subject Terms: |
DROSOPHILA melanogaster, NEURAL circuitry, CENTRAL nervous system, PROTEINS, DENDRITES |
| Abstract: |
In recent years. Drosophila melanogaster has emerged as a powerful model for neuronal circuit development, pathology, and function. A major impediment to these studies has been the lack of a genetically encoded, specific, universal, and phenotypically neutral marker of the somatodendritic compartment. We have developed such a marker and show that it is effective and specific in all neuronal populations tested in the peripheral and central nervous system. The marker, which we name DenMark (Dendritic Marker). is a hybrid protein of the mouse protein ICAM5/Telencephalin and the red fluorescent protein mCherry. We show,that DenMark is a powerful toot for revealing novel aspects of the neuroanatomy of developing dendrites. identifying previously unknown dendritic arbors, and elucidating neuronal connectivity. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
